A study to know the effect of chinnadi kashaya in migraine headache

Phase 3

Not yet recruiting

Conditions: Migraine without aura. Ayurveda Condition: ARDHAVABEDAKAH,

Registration Number: CTRI/2025/04/084416

Lead Sponsor: Muniyal instutute of ayurveda medical sciences,manipal,udupi.

Brief Summary: Migraine is the second most common cause of headache-related & indeed neurologic cause of disability in the world, it afflicts 15% of women & 6% of men over a year.

In Ayurveda, Ardhavabhedaka can be correlated with migraines. Acharya Charaka has specifically mentioned lakshanas of Ardhavabhedaka where Vedana in Ardha part of Shirah, Manya, Bhru, Sankha, Karna, Akshi & Lalata which is said to be shastra arni - nibha shoola. If left untreated, in extreme conditions, it can lead to Nasha of Nayanam & Shrotram.

Migraine is a syndrome of episodic recurrent headache, often unilateral, which is associated with nausea, vomiting, photophobia, or phonophobia. Women are more likely to experience migraines than males (2 to 3:1).

Migraine is one of the most common reasons for people to seek medical attention. Being the most severe type of headache, migraine sometimes has dramatic features of transient neurologic deficits, blinding headaches, nausea, and vomiting.

According to the World Health Organization, migraine is the third most frequent condition in the world with an estimated global frequency of 14.7%.

Drugs like Triptans and Ergotamine Tartrate are used in the treatment of Migraine, which is expensive and not commonly used in resource-poor countries. Many adverse effects, some of which may be minor or temporary, have been reported with migraine medications.

Another problem is the overuse of medicines, which causes medication overuse headaches (MOH), further complicating management strategies. Moreover, 5HT 1B/1D receptor agonist type of drugs used in migraine are contraindicated in individuals with a history of cardiovascular & cerebrovascular diseases. The average efficacy rate of oral agents is 50-70%.

Ayurvedic treatments for migraine are often favored due to their holistic approach, which aims to address the root cause rather than just symptoms. Ayurvedic management of migraine typically involves a combination of lifestyle modifications, dietary changes, herbal supplements, and therapies to balance the bodily doshas (Vata, Pitta, and Kapha).

Therefore, a treatment that provides results with no or very few side effects is needed to improve the quality of life of patients suffering from migraines. Treatment for relief and prevention of recurrence of the disease is necessary.

Hence, in this study, an effort will be made to assess the efficacy of Chinnadi Kashaya in managing Ardhavabhedaka and its comparison with Pathyaksadhatryadi Kashaya.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 40

Inclusion Criteria

1)Patients with classical signs and symptoms of ardhavabhedaka(Common migraine) as mentioned in diagnostic criteria.
1. Patients aged between 18 to 60 years.
3)Patients irrespective of gender, religion, or occupation.
4)patients are willing to participate in the trial.

Exclusion Criteria

1)Patients prediagnosed with tension headache or any other form of headache.
2)Patients prediagnosed with meningitis, brain tumors, encephalitis, cervical spondylosis, and also headaches due to refractive errors, glaucoma, and inflammatory diseases of the ear and nose.
1. Patients prediagnosed with coronary artery disease, uncontrolled diabetes, and accelerated hypertension 4)Patients prediagnosed with any malignancy, HIV, and any other chronic diseases.
1. Pregnant and lactating women.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To reduce the intensity of headache	15 days

Secondary Outcome Measures

Name	Time	Method
To reduce frequency of headache, duration of headache, nausea, vomiting, photophobia, phonophobia.	30 days

Trial Locations

Locations (1): Muniyal institute of ayurveda medical sciences, manipal,udupi
🇮🇳
Udupi, KARNATAKA, India
Muniyal institute of ayurveda medical sciences, manipal,udupi
🇮🇳Udupi, KARNATAKA, India
Dr Kalunge Chetan Mahadev
Principal investigator
9970434296
chetukalunge143@gmail.com