CROSS II.
Completed
- Conditions
- Esophageal cancer.
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 350
Inclusion Criteria
18 < age < 75 year, surgical resectable T2-3, N0-1, M0, tumour length longitudinal <8cm and radial <5cm, no invasion tracheobronchial tree, tumour must not extend more than 2 cm into the stomach, ECOG 0-2.
Exclusion Criteria
T1N1, T1N0, past or current history of malignancy other than entry diagnosis, previouw chemotherapy or radiotherapy, MI in last 6 months, congestive heart failure or arrhythmia requiring medication, neurotoxicity grade >1, inadequate caloric and or fluid intake, weight loss 10%.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. To compare median survival rates between patients treated for surgical resectable esophageal adenocarcinoma or squamous cell carcinoma;<br /><br>2. To compare quality of life before, during and after treatment.
- Secondary Outcome Measures
Name Time Method 1. To compare pathological responses; <br /><br>2. Progression free survival; <br /><br>3. Number of R0 resections; <br /><br>4. Treatment toxicity; <br /><br>5. Costs.