eoadjuvant chemoradiation followed by surgery versus surgery alone for patients with adenocarcinomas or squamous cell carcinomas of the esophagus

Completed

• Conditions: Esophageal cancer; Malignant neoplasm of oesophagus; Cancer

• Registration Number: ISRCTN80832026
• Lead Sponsor: Erasmus Medical Center, Department of Medical Oncology (Netherlands)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2006-01-27
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 350

Inclusion Criteria

1. Age >18, <75 years
2. Surgical resectable T2-3, N0-1, M0
3. Tumour length longitudinal <8 cm and radial <5 cm
4. No invasion tracheobronchial tree
5. Tumour must not extend more than 2 cm into the stomach
6. ECOG 0-2

Exclusion Criteria

1. T1N1
2. T1N0
3. Past or current history of malignancy other than entry diagnosis
4. Previous chemotherapy or radiotherapy
5. MI in last 6 months
6. Congestive heart failure or arrhythmia requiring medication
7. Neurotoxicity grade >1
8. Inadequate caloric and or fluid intake
9. Weight loss 10%

Study & Design

• Study Type: Interventional
• Study Design: Not specified