eoadjuvant chemoradiotherapy plus surgery versus active surveillance for oesophageal cancer
Not Applicable
Completed
- Conditions
- <p>Oesophageal cancer, oesofaguscarcinoom, esophageal cancer, active surveillance</p>10017998
- Registration Number
- NL-OMON25016
- Lead Sponsor
- Erasmus MC
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 300
Inclusion Criteria
- Patients who are planned to undergo neoadjuvant chemoradiotherapy according to CROSS, followed by surgical resection for histologically proven oesophageal squamous cell carcinoma or adenocarcinoma of the oesophagus or oesophago-gastric junction, without distant dissemination;
- Age =18;
Exclusion Criteria
- Language difficulty, dementia or altered mental status prohibiting the understanding and giving of informed consent and to complete quality of life questionnaires;
- Non-FDG-avid tumour at baseline PET-CT scan.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>- Overal survivall</p><br>
- Secondary Outcome Measures
Name Time Method <p>- Percentage of patients in active surveillance arm who do not undergo surgery (i.e. patients who are cured by neoadjuvant chemoradiotherapy or who have occult distant metastases during initial staging.</p><br>