Chemotherapy followed by versus surgery alone in high-risk patients with colorectal liver metastases
- Conditions
- Colorectal liver metastases, clinical risk score, high risk patients, colorectale levermetastasen, klinische risico score, hoog risico patienten
- Registration Number
- NL-OMON27498
- Lead Sponsor
- Prof. Dr. C. VerhoefErasmus MC Cancer Institute
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 224
Inclusion Criteria
Age ≥ 18 years
- ECOG performance status 0 or 1
Exclusion Criteria
- Prior adjuvant chemotherapy for the primary colorectal carcinoma given <6 months prior to detection of the liver metastases.
- Prior non colorectal malignancies, except for patients with basal or squamous cell carcinoma of the skin, or patients with carcinoma in situ of the cervix.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Overall Survival (OS)
- Secondary Outcome Measures
Name Time Method Progression free survival (PFS), quality of life, treatment response on chemotherapy, morbidity of resection, predictive value of carcinoembryonic antigen (CEA) for treatment response, PFS and OS