Effects of Volatile Anaesthetics on Incidence of Postoperative Depression and Anxiety in Elderly Patients

Completed

• Conditions: Cohort Studies
• Interventions: Drug: volatile anaesthetic (sevoflurane, isoflurane, desflurane)

• Registration Number: NCT06307717
• Lead Sponsor: Chinese PLA General Hospital

Brief Summary

This study is a retrospective analysis of a large-scale multicentre prospective cohort study that investigates the impact of volatile anaesthetics on the incidence of postoperative depression and anxiety among elderly patients.

Detailed Description

Studies have suggested volatile anaesthetics may alleviate depression and anxiety in patients. However, there is a paucity of research in this area. The investigatorswanted to determine the association between volatile anaesthetics and depression/anxiety in elderly patients within 7 days after surgery.

This study retrospectively analysed data from a prospective database of patients aged 65 and above who underwent non-cardiac, non-neurosurgical elective surgery in 18 tertiary hospitals across 10 provinces in China. Patients receiving volatile anaesthetics received at least one volatile anaesthetic (sevoflurane, isoflurane, desflurane), and those who received non-volatile anaesthetics did not receive any volatile anaesthetic. Binary logistic regression analyses were conducted, and propensity score-matching (PSM) and subgroup analyses were also applied.

Study Timeline

• Study Start: 2020-04-01
• Primary Completion: 2021-10-31
• Study Completion: 2022-04-30
• Study First Submitted: 2024-03-06
• Study First Submitted QC: 2024-03-06
• Study First Posted: 2024-03-13
• Status Verified: 2024-04
• Last Update Submitted: 2024-04-09
• Last Update Posted: 2024-04-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 8000

Inclusion Criteria

Geriatric surgical patients ≥65 years old Non-selective cardiac surgery Non-neurosurgical

Exclusion Criteria

1. underwent reoperation within 7 days
2. ASA classification of Ⅳ or above
3. history of serious mental illness or long-term use of psychotropic drugs
4. patients either died or were transferred to the intensive care unit within 7 days of the surgery
5. subjects with missing covariate data

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
volatile anaesthetic (sevoflurane, isoflurane, desflurane）	volatile anaesthetic (sevoflurane, isoflurane, desflurane)	Patients receiving volatile anaesthetics received at least one volatile anaesthetic (sevoflurane, isoflurane, desflurane), and those who received non-volatile anaesthetics did not receive any volatile anaesthetic.

Primary Outcome Measures

Name	Time	Method
Depression	Depression within 7 days of surgery	Primary outcomes were depression Patient Health Questionnaire 9 (PHQ-9).The PHQ-9 is a nine-item questionnaire for screening on the presence of depressive symptoms and monitoring depression severity. Items were scored on a four-point scale with total scores ranging from zero to twenty-seven. Scores were defined as: ≥5 mild, ≥10 moderate, and ≥15 severe level of depression. The recommended screening cutoff was ≥10, corresponding with at least a moderate level of depression. The higher the score, the worse the situation. The total score ranges from 0 to 27, and higher scores indicate more depressive symptoms.

Secondary Outcome Measures

Name	Time	Method
Anxiety	Anxiety within 7 days of surgery	The GAD-7 is a seven-item questionnaire for screening on the presence of generalized anxiety disorder and assessing its severity. Items were scored on a four-point scale with total scores ranging from zero to twenty-one. Scores were defined as: ≥5 mild, ≥10 moderate, and ≥15 severe anxiety. The recommended screening cutoff was ≥10, corresponding with at least a moderate level of anxiety. Higher scores mean more anxiety.

Trial Locations

Locations (1)

Chinese PLA General Hospital; 🇨🇳 Beijing, Beijing, China