The impact of ingesting milk versus free amino acids on muscle protein synthesis in healthy young adults

Completed

• Conditions: To assess the anabolic response following protein ingestion; muscle growth; muscle protein synthesis

• Registration Number: NL-OMON44413
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 24

Inclusion Criteria

1) Aged 18-35 y
2) BMI 18.5-27.5 kg/m2
3) Healthy, recreationally active, young adults

Exclusion Criteria

1) Allergies to milk protein
2) Lactose intolerance
3) PKU disease
4) Smoking
5) Diagnosed diabetes
6) Diagnosed metabolic or intestinal disorders
7) A history of neuromuscular problems
8) Any medications known to (or may) affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications)
9) Participation in structured resistance exercise program
10) Pregnant
11) Hormone replacement therapy
12) Third generation oral contraceptives
13) Strict vegetarian

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>muscle bound L-[ring-2H5]-phenylalanine, L-[1-13C]-phenylalanine, and<br /><br>L-[1-13C]-leucine enrichments (in MPE)<br /><br>plasma L-[ring-2H5]-phenylalanine and L-[1-13C]-leucine enrichments (in MPE)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Plasma amino acid, glucose en insulin concentrations, whole-body metabolism</p><br>