Based on PI3K/AKT/HIF-1 signaling pathway, to explore the clinical efficacy and mechanism of Zuoguiyin intervention in oxidative stress in the treatment of premature ovarian insufficiency
- Conditions
- Premature ovarian insufficiency
- Registration Number
- ITMCTR2023000069
- Lead Sponsor
- Xinjiang Uygur Autonomous Region Hospital of Traditional Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Female
- Target Recruitment
- Not specified
(1) Meet the diagnostic criteria of premature ovarian insufficiency in accordance with the guidelines of the European Society of Human Reproduction and Embryology (ESHRE) and the Chinese Expert Consensus on the Clinical Diagnosis and Treatment of premature ovarian insufficiency in 2017;
(2) meet the TCM syndrome standard of kidney Yin deficiency;
(3) Those who are willing to sign informed consent and cooperate with research investigators.
(4) Patients who have not used any hormone drug therapy in the past 3 months and have no contraindications to hormone therapy;
1) Pregnancy, abnormal reproductive tract development, complete androgen insensitivity syndrome, Asherman
Syndrome, polycystic ovary syndrome, thyroid disease, empty sella syndrome, central nervous system tumor, functional hypothalamic amenorrhea, ovarian resistance syndrome, etc.
(2) diabetes or abnormal blood sugar;
(3) Patients with heart, liver, spleen, lung, kidney, brain, blood, nervous, mental and other system diseases;
(4) Poor scientific research compliance and incomplete data;
(5) Patients who do not cooperate with the collection of physical type information.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method TCM syndrome integral;
- Secondary Outcome Measures
Name Time Method Six gonads;Menstrual score;Superoxide dismutase;catalase;AMH;Glutathione peroxidase;