The Body's Response to Food Intake in Older Adults

Not Applicable

Completed

• Conditions: Elderly
• Interventions: Dietary Supplement: Fluid Supplement; Dietary Supplement: Solid Supplement

• Registration Number: NCT00798408
• Lead Sponsor: Purdue University

Brief Summary

We propose to critically evaluate the effects of energy-yielding fluids and solids on acute appetite variables, daily food intake, and specific endocrine and metabolic response to food in the elderly. The results of these studies will provide further evidence to support that nutrition may provide safe and effective non-pharmacological therapies to counter the compromised regulation of energy balance experienced by many elderly people.

Detailed Description

Not available

Study Timeline

• Study Start: 2006-02
• Primary Completion: 2007-10
• Study Completion: 2008-01
• Study First Submitted: 2008-11-25
• Study First Submitted QC: 2008-11-25
• Study First Posted: 2008-11-26
• Status Verified: 2009-12
• Last Update Submitted: 2013-09-23
• Last Update Posted: 2013-09-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 35

Inclusion Criteria

• Age range: 60 years and older
• Body mass index between 20-29 kg/m2
• Weight stable (< 2 kg weight change within last 6 months)
• Non-smoking
• Constant habitual activity patterns within last 3 months
• Clinically normal blood profiles (specifically, normal liver and kidney function; normal complete blood count (non-anemic); fasting blood glucose <110 mg/dl)
• Not taking medications known to influence appetite or metabolism
• Non-diabetic
• Resistive exercise training (≤2 times a week) based on reported physical activity levels (questionnaire)
• Active fitness level (≤3, 30-minute aerobic exercise sessions/week)
• Confirmation of acceptability of eating the study test foods (solids and fluids)

Exclusion Criteria

• Age: <60 years
• Body mass index: outside of the 20-29 kg/m2 range
• Gained or lost > 4.5 kg within the last 6 months
• Smoker (currently or within the last year)
• Intermittently been involved in a diet and/or exercise program within the last 3 months
• Clinically abnormal blood profiles as identified by our study physician, Arthur Rosen, MD
• Taking medications (currently or within the last 3 months) known to influence appetite or metabolism
• Abnormal heart function (interpreted by a cardiologist) and assessed (for study exclusion) by our study physician, Arthur Rosen, MD
• Clinically diagnosed as diabetic
• Did not perform resistive exercise training (currently or within the last 3 months) based on reported physical activity levels (questionnaire)
• Perform ≥ 2, 30-minute aerobic exercise sessions/week (currently or within the last 3 months) based on physical activity levels (questionnaire)
• Study foods are found to be unacceptable for consumption by the subject

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
1	Fluid Supplement	Participants will maintain current physical activity and take a fluid supplement.
2	Solid Supplement	Participants will maintain current physical activity and take a solid supplement.

Primary Outcome Measures

Name	Time	Method
Quantify the acute effects of fluid and solid foods on post-prandial (post-meal) appetite and food intake at the next eating occasion in untrained older men and women	3 weeks

Secondary Outcome Measures

Name	Time	Method
Quantify the contribution of selected satiety factors (glucose, insulin, CCK, ghrelin, and GLP-1) and post-prandial energy expenditure to the differential appetitive responses to fluid versus solid foods in untrained older men and women	3 weeks

Trial Locations

Locations (1)

Purdue University; 🇺🇸 West Lafayette, Indiana, United States