NCT00798408已完成不适用
The Body's Response to Food Intake in Older Adults
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 35
- 试验地点
- 2
- 主要终点
- Quantify the acute effects of fluid and solid foods on post-prandial (post-meal) appetite and food intake at the next eating occasion in untrained older men and women
研究概览
简要总结
We propose to critically evaluate the effects of energy-yielding fluids and solids on acute appetite variables, daily food intake, and specific endocrine and metabolic response to food in the elderly. The results of these studies will provide further evidence to support that nutrition may provide safe and effective non-pharmacological therapies to counter the compromised regulation of energy balance experienced by many elderly people.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age range: 60 years and older
- •Body mass index between 20-29 kg/m2
- •Weight stable (< 2 kg weight change within last 6 months)
- •Non-smoking
- •Constant habitual activity patterns within last 3 months
- •Clinically normal blood profiles (specifically, normal liver and kidney function; normal complete blood count (non-anemic); fasting blood glucose <110 mg/dl)
- •Not taking medications known to influence appetite or metabolism
- •Non-diabetic
- •Resistive exercise training (≤2 times a week) based on reported physical activity levels (questionnaire)
- •Active fitness level (≤3, 30-minute aerobic exercise sessions/week)
- •Confirmation of acceptability of eating the study test foods (solids and fluids)
排除标准
- •Age: <60 years
- •Body mass index: outside of the 20-29 kg/m2 range
- •Gained or lost > 4.5 kg within the last 6 months
- •Smoker (currently or within the last year)
- •Intermittently been involved in a diet and/or exercise program within the last 3 months
- •Clinically abnormal blood profiles as identified by our study physician, Arthur Rosen, MD
- •Taking medications (currently or within the last 3 months) known to influence appetite or metabolism
- •Abnormal heart function (interpreted by a cardiologist) and assessed (for study exclusion) by our study physician, Arthur Rosen, MD
- •Clinically diagnosed as diabetic
- •Did not perform resistive exercise training (currently or within the last 3 months) based on reported physical activity levels (questionnaire)
- •Perform ≥ 2, 30-minute aerobic exercise sessions/week (currently or within the last 3 months) based on physical activity levels (questionnaire)
- •Study foods are found to be unacceptable for consumption by the subject
结局指标
主要结局
Quantify the acute effects of fluid and solid foods on post-prandial (post-meal) appetite and food intake at the next eating occasion in untrained older men and women
时间窗: 3 weeks
次要结局
- Quantify the contribution of selected satiety factors (glucose, insulin, CCK, ghrelin, and GLP-1) and post-prandial energy expenditure to the differential appetitive responses to fluid versus solid foods in untrained older men and women(3 weeks)
研究者
Wayne Campbell
Professor, Foods and Nutrition
Purdue University
研究点 (2)
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