Neural Correlates of Self

Not Applicable

Completed

• Conditions: Healthy Volunteers
• Interventions: Behavioral: "control", "meditation", "hypnosis".

• Registration Number: NCT03206840
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Despite the increasing popularity of mindfulness meditation and hypnosis in healthcare and in the general community the underlying neurobiological mechanisms are unclear. The change in the relationship between the self and the conscious experience that they bring about may be crucial. This study aims to identify the neural correlates of self-consciousness in meta-awareness and absorption - using functional Magnetic Resonance Imaging (fMRI) in healthy participants combined with detailed first-person experiential accounts and behavioural tasks. This study will provide important clues about the widely reported effects of mindfulness meditation and hypnosis and shed light on the neural correlates of the conscious experience of self.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-06-30
• Study First Submitted QC: 2017-06-30
• Study First Posted: 2017-07-02
• Study Start: 2017-10-26
• Primary Completion: 2018-11-12
• Study Completion: 2018-11-12
• Status Verified: 2019-03
• Last Update Submitted: 2019-03-06
• Last Update Posted: 2019-03-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• aged 18-70
• Body mass index between 18.5 and 30
• Covered by health insurance
• motivated to participate
• signed informed consent
• normal or corrected-to-normal eyesight
• sufficient command of French to be able to follow the instructions

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Exclusion Criteria

• history of neurological or psychiatric conditions
• chronic pain or another medical condition altering pain perception
• use of medication that affects the central nervous system
• use of opioids or antidepressant medication
• severe auditory loss
• consumption of alcohol or intoxicants on the day of the experiments and the day preceding the experiments
• pregnancy, breastfeeding or having given birth <6months ago
• any contra-indication to Magnetic Resonance Imaging (metal implants or foreign bodies), agitation, claustrophobia

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Group 1	"control", "meditation", "hypnosis".	three instructions will be given to each participant: "control", "meditation", "hypnosis". The order of "meditation" and "hypnosis" will be randomized amongst two groups to avoid order effects.
Group 2	"control", "meditation", "hypnosis".	three instructions will be given to each participant: "control", "meditation", "hypnosis". The order of "meditation" and "hypnosis" will be randomized amongst two groups to avoid order effects.

Primary Outcome Measures

Name	Time	Method
Reaction time (minutes)	at day 1	reaction times during behavioural tasks.
Brain activation with IRM	At day 3	Activation of different brain areas, as measured with functional Magnetic Resonance

Secondary Outcome Measures

Name	Time	Method
Scores during behavioural tasks	at day 3	scores on likert scale (1-5 and 1-9) about intensity of the stimui presented during the task
salivary volume (millimeter)	at day 1	salivary volume after behavioural tasks
personality trait with questionnaires	at day 2	scores on different personality questionnaires

Trial Locations

Locations (1)

Hospices Civils de Lyon Hôpital le Vinatier/Inserm; 🇫🇷 Bron, France