NCT04594265Unknown2 期
Weight-Adjusted Dosing of 3-OHB in Patients With Chronic Heart Failure
适应症
试验速览
- 阶段
- 2 期
- 入组人数
- 8
- 试验地点
- 2
- 主要终点
- Cardiac Output (L/min)
研究概览
简要总结
We aim to investigate the hemodynamic effects of weight-adjusted dosing of ketone monoester en patients with chronic heart failure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- •Diabetes or HbA1c >48 mmol/mol, significant cardiac valve disease, severe stable angina pectoris, severe comorbidity as judged by the investigator, inability to give informed consent
结局指标
主要结局
Cardiac Output (L/min)
时间窗: 3 hours - Area under the curve
Change in Cardiac output measured by Swann-Ganz Catherization during study period,
次要结局
- Blood Ketones(3 hours)
- Blood pH(3 hours)
- Left Ventricular Ejection Fraction(3 hours - Area under the curve)
研究者
Kristian Hylleberg Christensen
MD
Aarhus University Hospital
研究点 (2)
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