Transcranial Direct Current Stimulation in Post-stroke Fatigue
- Conditions
- FatigueStroke
- Interventions
- Device: Anodal tDCSDevice: sham tDCS
- Registration Number
- NCT04634864
- Lead Sponsor
- University College, London
- Brief Summary
This is a double-blind, sham-controlled, anodal tDCS study to understand the effect of increasing motor cortex excitability on post-stroke fatigue.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 33
Diagnosed with stroke at least 3 months post-stroke
Other neurological conditions on Anti-depressants severe motor impairment (affected hand grip <60% unaffected hand) severe cognitive impairment (unable to follow instructions, or give informed consent) scored >11 in the depression sub-section of HADS questionnaire contraindications for TMS or tES
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Anodal tDCS Anodal tDCS 40 minutes of 2mA intensity direct current stimulation sham tDCS sham tDCS 40 minutes of 0mA intensity. the session starts with a ramp up to 2mA, but machine is switched off after 2 minutes of stimulation.
- Primary Outcome Measures
Name Time Method Fatigue Severity Scale - 7 2 weeks a questionnaire based fatigue scale
- Secondary Outcome Measures
Name Time Method Input-output curves 1 day This is a measure of cortical recruitment as measured by transcranial magnetic stimulation
Perceived effort - Explicit 1 day A VAS scale associated with a grip task
Resting Motor Threshold 1 day This is a measure of cortical excitability as measured by transcranial magnetic stimulation
Perceived effort - Implicit 1 day A novel line length estimation task
Trial Locations
- Locations (1)
33 Queen Square, Institute of Neurology, UCL
🇬🇧London, United Kingdom