3 Ultrasound Guided Plane Blocks for Perioperative Analgesia in Patients Undergoing Radical Cystectomy

Not Applicable

Completed

• Conditions: Anesthesia; Analgesia; Cancer, Bladder; Block; Surgery
• Interventions: Procedure: Erector Spinae Plane Block; Procedure: Thoracic Paravertebral Plane Block; Procedure: Quadratus Lumborum Plane Block

• Registration Number: NCT05278598
• Lead Sponsor: Nazmy Edward Seif

Brief Summary

Radical cystectomy is the gold standard treatment for muscle invasive bladder cancer as well as some T1 and non-invasive disease. It is a major operation with significant perioperative morbidity and complications. Pain is one of the most important complications to be managed.

Regional blocks as a part of multi-modal analgesia are considered main strategies of Enhanced Recovery after Surgery (ERAS) decreasing post-operative complications including post-operative pain and post-operative hospital stay. They also have an upper hand over systemic intravenous opioids decreasing the risk for post-operative delirium specially in old age patients. Thoracic paravertebral plane block (TPVPB), intra muscular quadratus lumborum plane block (QLPB) and erector spinae plane block (ESPB) are among these regional anesthesia techniques for pain management.

Erector spinae plane block is an emerging block, with low risk and more feasibility, but efficacy hasn't been compared to quadratus lumborum and paravertebral plane blocks altogether in radical cystectomy surgeries.

All these blocks are effective in reducing postoperative pain and the need of analgesia in radical cystectomy surgery; this is a comparative study between the three blocks in this population.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-03-04
• Study First Submitted QC: 2022-03-04
• Study First Posted: 2022-03-14
• Study Start: 2022-03-27
• Primary Completion: 2023-08-16
• Study Completion: 2023-08-16
• Status Verified: 2024-05
• Last Update Submitted: 2024-05-07
• Last Update Posted: 2024-05-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• American Society of Anesthesiologists (ASA) class II - III.
• Adult patients scheduled for radical cystectomy.

Exclusion Criteria

• Patient refusal.
• Uncooperative patients.
• Patients with known allergies to local anesthetics.
• Bleeding disorders or coagulopathy.
• Anatomical abnormality or infection at injection site.
• Patients receiving opioids for chronic analgesic therapy.
• Spinal anesthesia or any other regional anesthesia.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
ESPB group	Erector Spinae Plane Block	Erector Spinae Plane Block
TPVPB group	Thoracic Paravertebral Plane Block	Thoracic Paravertebral Plane Block
QLPB group	Quadratus Lumborum Plane Block	Quadratus Lumborum Plane Block

Primary Outcome Measures

Name	Time	Method
Morphine consumption.	24 hours	Total dose of Morphine (measured in mg) given intra-venously to the patient post-operatively.

Trial Locations

Locations (1)

Cairo University Hospitals; 🇪🇬 Cairo, Egypt