The brain effect and mechanism of ''Shuji acupoint'' acupuncture on the brain functional connectivity network of PATIENTS with IBS based on the rs-fMRI technique
- Conditions
- Irritable bowel syndrome
- Registration Number
- ITMCTR2200005558
- Lead Sponsor
- the Second Affiliated Hospital of Anhui University of Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
Included in the standard
(1) Roman ? diagnostic criteria;
(2) 20-60 years old;
(3) The course of disease is more than 6 months;
(4) HAMA score is 7 or above;
(5) Unexplained symptoms of structural abnormalities and physiological and pathological abnormalities;
(6) No metal implants in the body, and no contraindications of fMRI detection;
(7) Have not used any IBS drugs (except for emergency treatment) for at least 2 weeks before the initiation of treatment, have not received acupuncture treatment for IBS in the recent 3 months, and have not participated in other ongoing clinical investigators;
(8) Have not received formal psychological treatment or psychiatric drug treatment, and have not used any psychotropic drugs in recent 2 weeks;
(9) right-handed;
(10) The subject signed the informed consent and voluntarily participated in the study;
Note: Patients who meet the above 10 criteria at the same time can be included in this study.
Exclusion criteria
(1) have intestinal organic lesions (such as ulcerative colitis, Crohn's disease), or systemic diseases affecting digestive tract motility (such as advanced thyroid function, hypopituitary function, systemic lupus erythematosus, alcoholic liver disease, etc.);
(2) patients with serious primary diseases such as cardiovascular system, digestive system, hematopoietic system, mental system, liver and kidney;
(3) have a history of abdominal or rectoanal surgery;
(4) people who regularly take drugs that affect gastrointestinal motility or change intestinal flora;
(5) during pregnancy, lactation, postpartum years and allergic constitution;
(6) Patients with severe anxiety whose HAMA score =29;
(7) Those who have a history of headache or brain trauma, or have a history of dependence on psychoactive substances such as alcohol, or have obvious intellectual disabilities;
(8) Subjects with claustrophobia and other contraindications;
(9) Severe anatomical asymmetry of the skull or definite lesions found in the scan;
(10) Unable to cooperate with the completion of this study.
Note: Patients who meet any of the above criteria are excluded.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Resting state fMRI scan;
- Secondary Outcome Measures
Name Time Method