Brain imaging mechanism of acupuncture for post-stroke non-fluent aphasia: a multi-modal MRI study
- Conditions
- Post-stroke aphasia
- Registration Number
- ITMCTR2100004969
- Lead Sponsor
- Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
1. Patients with aphasia after Ischemic stroke<=6months; aged 35 to 80 years old;
2. Chinese as first language, right-handed;
3. Diagnosed as non-fluent aphasia by Western Aphasia Battery(WAB), Boston Diagnostic Aphasia Examination >= 1;
4. Primary school education or above;
5. Signed informed consent
1. Severe hearing impairments or dysarthria or cognitive impairments likely to affect adherence to study protocol;
2. Aphasia owing to other brain injury or neurodegenerative disease besides stroke;
3. Severe heart, liver, kidney damage likely to influence participation;
4. Patients taking transcranial direct current stimulation (tDCS) therapy or piperacetam, donepezil, memantine, bromocytine, galantamine and not able to discontinue those therapies after being included in the study;
5. Having MRI contraindications.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Boston Diagnostic Aphasia Examination(BDAE);
- Secondary Outcome Measures
Name Time Method Volumetric and cortical thickness data;Diffusion tensor imaging;Western Aphasia Battery(WAB);Resting-state fMRI data;