Effect of Gastric Cancer Surgical Resection Extent on Postoperative Gallstone Formation: A Retrospected Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 531
- 试验地点
- 2
- 主要终点
- Number of gallstone patients
研究概览
简要总结
To provide preventive and therapeutic strategies for participants with gallstones after gastric cancer by comparing the risk of postoperative gallbladder stone formation with two different resection ranges using the Roux-en-Y reconstruction modality in radical gastric cancer surgery.
详细描述
A large number of clinical studies have found that the incidence of gallstones in patients after radical gastric cancer surgery is higher than that in the normal population. However, the pathogenesis has not been clarified, and the prophylactic removal of the gallbladder in patients with gastric cancer remains controversial. A previous study found a statistically significant incidence of gallbladder stones after Billroth I versus Roux-en-Y in distal gastrectomy for gastric cancer. Therefore, the investigators plan to conduct a retrospected cohort study to collect further participants with gastric cancer who underwent total gastrectomy to answer whether different surgical resection ranges during surgery increase the incidence of gallstones this question.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with Gastric Cancer underwent Gastrectomy
排除标准
- •Age less than 18 years or age greater than 75 years;
- •Not Roux-en-Y reconstruction;
- •R0 excision is not achieved;
- •Previous history of upper abdominal surgery, such as cholecystectomy, gastrectomy;
- •Preoperative gallbladder diseases, such as gallstones, gallbladder polyps, chronic cholecystitis;
- •Preoperative neoadjuvant chemotherapy or radiotherapy;
- •Previous history of malignant tumours;
- •Patients with mental or developmental abnormalities or women during pregnancy or breastfeeding;
- •Gastric perforation or bleeding leading to emergency surgery;
- •Palliative surgical treatment;
- •Incomplete case information.
结局指标
主要结局
Number of gallstone patients
时间窗: 5years
Two groups of patients with gastric cancer had a follow-up for more than one year and the number of patients with gallbladder stones on B-ultrasound or Computed Tomography (CT)
次要结局
- Number of patients with bile duct stones(5years)
- Number of patients with postoperative complications(5years)
研究者
Wenbo Meng
Director of Surgery
Hepatopancreatobiliary Surgery Institute of Gansu Province