Cognitive Inhibition, Psychosocial Interactions and Suicide Attempt in Elderly

Not Applicable

• Conditions: Suicide

• Registration Number: NCT02858427
• Lead Sponsor: Centre Hospitalier Universitaire de Besancon

Brief Summary

The study aims to determine the correlation between the cognitive inhibition impairment and the history of suicide attempt in elderly depressed patients.

Detailed Description

2 groups of patients will be studied: in the first group, depressed patients with a history of suicide attempt will be included whereas in the second group, depressed patients without a history of suicide attempt will be included.

For each group, the cognitive inhibition will be assessed trough an eye tracker task (antisaccade).

Both groups will also be compared on their neuropsychological characteristics and the quality of social interactions of participants.

Study Timeline

• Study First Submitted: 2016-08-01
• Study First Submitted QC: 2016-08-05
• Study First Posted: 2016-08-08
• Study Start: 2017-02-06
• Status Verified: 2017-10
• Last Update Submitted: 2017-10-12
• Last Update Posted: 2017-10-13
• Primary Completion: 2019-08-06
• Study Completion: 2020-02-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• major depressive disorder according to Diagnostic ans Statistical Manual (DSM) V
• group 1: with a history of suicide attempt
• group 2: without a history of suicide attempt

Exclusion Criteria

• other psychiatric disease
• guardianship

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Primary Outcome Measures

Name	Time	Method
antisaccade error rate	1 month max. after inclusion

Secondary Outcome Measures

Name	Time	Method
saccade reaction time	1 month max. after inclusion
social interaction quality score	6 month max. after inclusion
maximal speed of the gaze	1 month max. after inclusion	maximum speed of visual tracking without triggering any saccade
saccadic intrusion	1 month max. after inclusion	gaze deviation into a saccade greater than 3° during visual fixation
saccade accuracy	1 month max. after inclusion	distance between the eye position at the end of the first saccade, and the ideal position to engage the target in central vision
fixation duration on pictures	1 month max. after inclusion

Trial Locations

Locations (2)

CHU Besancon; 🇫🇷 Besancon, Doubs, France

CHS Bavilliers; 🇫🇷 Bavilliers, France