Efficacy of Pistacia lentiscus plant extract (Mastic gum) in comparison to Prucalopride in Type 2 diabetic patients with constipation- A randomized open label controlled trial

Gastrointestinal manifestations in type 1 and 2 diabetes are common and represent substantial causes of morbidity and health care costs as well as diagnostic and therapeutic challenge. Prucalopride, a selective serotonin agonist has been proved to have effect in both colon transit time as well as gastric emptying time and is an approved drug for constipation and is used in diabetic gastrointestinal neuropathies. There are some tolerable side effects of this drug in chronic use. Because of this, there is a need to find a drug, which can help to improve gastroparesis symptoms with sustainable effects. Mastic gum is not only a natural product with minimum or no side effects but also easily acceptable for most geriatric as well as younger diabetic population. Currently patients are being screened. Eligible patients will be recruited after obtaining clearance.