跳至主要内容
临床试验/CTRI/2025/03/082379
CTRI/2025/03/082379尚未招募不适用

RANDOMIZED CONTROLLED OPEN CLINICAL STUDY TO EVALUATE THE EFFICACY OF DUSHTAVRANPRASHAMAN LEPA IN THE MANAGEMENT OF DUSHTA VRANA W.S.R. TO INFECTED WOUND.

Dr.VJD Gramin Ayurved Mahavidyalaya1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2025年3月20日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
60
试验地点
1
主要终点
Symptoms Like1)Vedana (Pain)

研究概览

简要总结

Ayurveda is that which deals with Ayulife or longevity and Veda science

or knowledge.

Ayurveda is a collection of principles of healthy living that evolved from the

time of appearance of man on earth. This system is older than the Greek and

Egyptian medicine. It is known to the wider world as a New Age Medicine and it is

also called the mother of Healing.

DEFINATION:

Wound is a Break in Integrity of the Skin or tissue Often, Which May Be

Associated with disruption of the structure And function.

As a scar of a wound never disappears even after complete healing and its

imprint persists life long, it is called vrana.

In Ayurveda, particularly Sushruta has mentioned various types of vrana and

their management which is of prime importance in any surgical practice.

There are 6 Types of Vrana according to Acharya Sushruta –

Chinna,Bhinna,Viddha,Kshata,Picchita,Ghrushta. All the above are Sadyo Vrana

Which Get Converted in Dushta Vrana, if Not treated properly within 7 Days.

After injury, healing is a natural phenomenon and continues in sequential manner

until the formation as a healthy scar. Usually nature takes complete care during

healing. The defense mechanism of body like phagocytosis & its local enzymatic

action on dead tissue helps to keep wounds clean. But at time when infection is

massive, surface area of wound is very large and slough or necrotic tissue is to much,

this auto cleaning mechanism becomes inadequate. Acharya Sushruta was aware of

these facts and has indicated the process by which these impediments can be

removed thus paving way for uninterrupted healing.

For the management of dushta vrana he incorporated number of drugs broadly

classified into vranshodhana & vranropana. It is need to find out a rational and

optimal healing compound for the wound management in better

Way.

There are many measures to create favorable condition for wound healing

such as use of antiseptic solutions and many topical de-sloughing and debridement

agent which promote healing but there are certain drawbacks of these agents like

damage to healthy granulation tissue, local skin etc. Since time immemorial it has

been an ongoing process to search out better remedies in order to overcome the

previous draw backs.

Acharya Charak has stated that shodhan is perfect treatment for Dushta Vrana.

Infected wounds are more complicated to heal.generally requires

hospitalization but application of Dushtavranprashaman lepa is para-surgical

process which don’t need hospitalization. Also, it is more effective, multipurpose,

economically affordable and easy to use, also there are no chances for allergies.

Use Of Dushtavranprashaman Lepa in Dushta Vrana:

Acharya Sushruta has classified Lepa into three types: 1.Pralepa 2.Pradeha 3.Alepa

,he clearly indicated use of alepa in dushta vrana. Wound having features of

elevated muscular growth, hard, itching, difficult to clean should treated with

lepa.

研究设计

研究类型
Interventional
分配方式
Coin toss, Lottery, toss of dice, shuffling cards etc
盲法
None

入排标准

年龄范围
20.00 Year(s) 至 60.00 Year(s)(—)
性别
All

入选标准

  • Patient Having Signs and Symptoms of Dushta Vrana (Infected Wound).
  • Age 20-60 Yrs.
  • Patient of Either Sex Will Be Selected.
  • Dushta Vrana within Size Length Up to 5cm, Depth Up to 0.5 cm.
  • Superficial wound involving only epidermis and dermal papillae.

排除标准

  • Patient Suffering from Major Illness Like Cirrhosis, Ascites, Renal failure, DM,TB, Leprosy, Pregnancy, Jaundice, Varicosity, HIV, HBsAg, Malnutrition.
  • Patient With Malignancy.
  • Bleeding Disorder (Increased BT & CT).
  • Complex & Multiple Wound.
  • Diabetic wound.
  • Anaemic Patient Hb less than 9 g/dL.
  • Septicemia And Operative Wounds.
  • Medicolegal Cases.

结局指标

主要结局

Symptoms Like1)Vedana (Pain)

时间窗: 3,5,7,10,15 days

2)Kandu (Itching)

时间窗: 3,5,7,10,15 days

3)Varna (Color)

时间窗: 3,5,7,10,15 days

4)Gandha (Smell)

时间窗: 3,5,7,10,15 days

5)Strava (Discharge)

时间窗: 3,5,7,10,15 days

6)Slough

时间窗: 3,5,7,10,15 days

7)Granulation Tissue

时间窗: 3,5,7,10,15 days

次要结局

  • Decrease in Overall Symptoms(As per Follow up of patient mentioned)

研究者

发起方
Dr.VJD Gramin Ayurved Mahavidyalaya
申办方类型
Research institution and hospital
责任方
Principal Investigator
主要研究者

Dr Hemant Nanaji Thorat

Dr.VJD Gramin Ayurved Mahavidyalaya,Patur,Akola

研究点 (1)

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