Epidermal skin grafting: does it improve wound healing?
- Conditions
- chronic woundskin cancer10014982
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 140
Inclusion Criteria
-all patients who are sheduled to receive a skin transplant following skin
cancer excision surgery; all patients suffering from a chronic ulcer who are
sheduled to receive a SSG (split skin graft)
Exclusion Criteria
-the patient suffers from an oncologic ulcer in the wound area
-the patient is known with alcohol or drug abuse
-the patient cannot be informed correctly (e.g. because of language or mental
problems)
-the patient is unable to travel to the outpatient clinic for follow up visits
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Primary question:<br /><br>Does Epidermal Skin Grafting affect the wound healing of patients with acute<br /><br>and chronic wounds?<br /><br>The outcome measure of wound healing contains two variables, duration to total<br /><br>epithelialization and surface reduction per unit time. Both are measured using<br /><br>digital photography and independent assessment (total epithelialization) and<br /><br>digital photo analysis using the WHAT software (surface reduction).<br /><br>In the acute wound group without SSG, we expect faster wound healing by the ESG<br /><br>in the secondary healing donor site compared to the control group. In the acute<br /><br>and chronic wound group that is indicated for SSG, the ESG group is expected to<br /><br>display identical healing tendency as the SSG-receiving control group, but the<br /><br>benefit is in pain perception, more limited or absent appearance of the scar<br /><br>and an increased quality of life.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary questions:<br /><br>• What is the influence of ESG on the pain intensity of the donor and acceptor<br /><br>site during the treatment process? Pain is measured with NRS (Numeric Rating<br /><br>Scale) score<br /><br>• What is the quality of the scar of the secondary healing wound with ESG<br /><br>compared to the control group? The quality of the scar is measured with the<br /><br>validated POSAS method, whereby both the patient and the doctor give an opinion<br /><br>on, among other things, the redness, itching, swelling, lumpiness and pain of<br /><br>scars.<br /><br>• What is the influence on the patient's quality of life of both treatment<br /><br>routes? Quality of life is measured with the validated scales EQ5D (generic)<br /><br>and the Wound QoL (wound specific).</p><br>