Non-Invasive Brain Stimulation to Control Large-Scale Brain Networks

Not Applicable

Recruiting

• Conditions: Working Memory
• Interventions: Device: Transcranial alternating current stimulation

• Registration Number: NCT04680481
• Lead Sponsor: University of Minnesota

Brief Summary

This project will assess the feasibility of traveling wave transcranial alternating current stimulation (tACS) to modify working memory performance and large-scale brain connectivity in surgical epilepsy patients.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2020-11-01
• Study First Submitted: 2020-12-14
• Study First Submitted QC: 2020-12-17
• Study First Posted: 2020-12-23
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-16
• Last Update Posted: 2024-02-20
• Primary Completion: 2024-11-01
• Study Completion: 2024-11-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

1. the patient can consent for themselves;
2. the patient has or is scheduled for surgically implanted electrodes for the purposes of phase II epilepsy surgical evaluation;
3. age 18+ years old;

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Exclusion Criteria

1. diminished capacity to consent;

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Stimulation Theta Group	Transcranial alternating current stimulation	Participants will experience traveling wave transcranial alternating current stimulation over the fronto-parietal regions at 4 Hz (theta condition).
Stimulation Beta Group	Transcranial alternating current stimulation	Participants will experience traveling wave transcranial alternating current stimulation over the fronto-parietal regions at 23 Hz (beta condition).

Primary Outcome Measures

Name	Time	Method
Electrophysiological outcomes	Immediate effect during stimulation	Changes in spectral power and coherence of the local field potentials during transcranial electric stimulation relative to no stimulation periods.
Working memory outcomes	Immediate effect during stimulation	Changes in working memory performance as measured with the N-back task (quantified with d-prime) during stimulation.

Trial Locations

Locations (1)

University of Minnesota; 🇺🇸 Minneapolis, Minnesota, United States