A clinical trial to study the effects of prophylactic Ondansetron and Palonosetron for prevention of post spinal shivering.
Not Applicable
- Conditions
- Health Condition 1: V00-Y99- External causes of morbidity
- Registration Number
- CTRI/2021/08/035714
- Lead Sponsor
- Dayanand Medical College and Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients of either sex ,aged 18-60 years belonging to ASA I â??III, after written informed consent.
Exclusion Criteria
1. Failed spinal anaesthesia.
2. Prolonged surgical time leading to supplement/ conversion to general anaesthesia.
3. Any contraindication to spinal anaesthesia.
4. Patient needing blood transfusion.
5. Parkinsons disease.
6. Patient with known endocrine disease.
7. Diabetic autonomic neuropathy.
8. Patients having any dysarryrthmias on pre-operative ECG.
9. Known hypersensitivity to any of the drugs used in the study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the efficacy of prophylactic Ondansetron and Palonosetron in reducing the incidence and severity of post spinal shivering.Timepoint: The hemodynamic parameters, core and peripheral body temperature will be monitored perioperatively and in PACU at 30 minutes interval. Sensory and motor blockade will be assessed. Any episode of shivering will be recorded, graded as per Wrench.Grade3,4 will be given rescue drug Tramadol 50mg IVbolus.
- Secondary Outcome Measures
Name Time Method To observe hemodynamic changes and side effects ,if anyTimepoint: Hemodynamic parameters will be monitored perioperatively and in PACU for 6hours.