A randomized controlled trial of acute and maintenance Theta Burst Stimulation for the cognitive symptoms of mild to moderate Alzheimer’s: The MAINTAIN study.

Monash University0 个研究点目标入组 92 人开始时间: 2021年5月24日最近更新: 2022年4月19日

适应症

试验速览

暂无简介。

•Participants will be included if they:
•(1) are between 50 and 85 years;
•(2) are competent to consent based on their ability to provide a spontaneous narrative description of the key elements of the study, as assessed by an independent clinical staff member. Participants will complete an advanced care directive to allow for the possibility they may lose capacity during the trial;
•(3) have a diagnosis of probable Alz according to the National Institute on Aging /Alzheimer's Association diagnostic guidelines for Alzheimer's disease (NIA-AA)
•(4) meet criteria for mild or moderate Alz as indicated by >12 on the Mini-Mental State Evaluation; (5) are either not on a cholinesterase inhibitor or memantine or have been on a stable dose for at least 2 months prior to screening;
•(6) are either not on psychotropic medication or their dose of psychotropic medication has been unchanged for at least 4 weeks prior to study entry. Psychotropic medication dose will not be able to be altered during the trial: if this is clinically required the participant will be withdrawn;
•(7) have frequent contact with a close other who can provide information on the participant’s cognitive and functional abilities;
•(8) are able to participate in cognitive testing in English.

•Participants will be excluded if they:
•(1) have a concomitant major and unstable medical, psychiatric or neurological illness or seizure disorder history;
•(2) are pregnant;
•(3) have medically implanted material that could interact with the magnetic field.

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