General Anesthesia Combined With Epidural Anesthesia Mitigates the Surgical Stress-related Immunosuppression in Patients With Colorectal Cancer

Changhong Miao1 site in 1 country53 target enrollmentSeptember 2011

ConditionsColorectal Neoplasms

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Colorectal Neoplasms
Sponsor: Changhong Miao
Enrollment: 53
Locations: 1
Primary Endpoint: The changes of peripheral immune cells and cytokines
Status: Completed
Last Updated: 12 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to prove whether general anesthesia combined with epidural anesthesia could better maintain body balance of Th1/Th2 and Treg/Th17 compared with general anesthesia, so as to reduce the surgical stress-related immunosuppression, and to improve the prognosis.

Registry

clinicaltrials.gov

Start Date

September 2011

End Date

September 2012

Last Updated

12 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Changhong Miao

Responsible Party

Sponsor Investigator

Principal Investigator

Changhong Miao

Professor, Department of Anesthesiology

Fudan University

Eligibility Criteria

Inclusion Criteria

•patients with Colorectal Cancer(CRC);
•subjected to the Fast-Track processing of surgery;
•between 18 and 75 years old.

Exclusion Criteria

•American Society of Anesthesiologists(ASA) grade \> III;
•BMI \> 30;
•a history of abdominal surgery, endocrine or immune system dysfunction;
•recent blood transfusions, hormone or non-steroidal anti-inflammatory therapy during the past month;
•previous contraindication to epidural anesthesia.