General Anesthesia Combined With Epidural Anesthesia Mitigates the Surgical Stress-related Immunosuppression in Patients With Colorectal Cancer
Not Applicable
Completed
- Conditions
- Colorectal Neoplasms
- Registration Number
- NCT01978717
- Lead Sponsor
- Changhong Miao
- Brief Summary
The purpose of this study is to prove whether general anesthesia combined with epidural anesthesia could better maintain body balance of Th1/Th2 and Treg/Th17 compared with general anesthesia, so as to reduce the surgical stress-related immunosuppression, and to improve the prognosis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 53
Inclusion Criteria
- patients with Colorectal Cancer(CRC);
- subjected to the Fast-Track processing of surgery;
- between 18 and 75 years old.
Exclusion Criteria
- American Society of Anesthesiologists(ASA) grade > III;
- BMI > 30;
- a history of abdominal surgery, endocrine or immune system dysfunction;
- recent blood transfusions, hormone or non-steroidal anti-inflammatory therapy during the past month;
- previous contraindication to epidural anesthesia.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method The changes of peripheral immune cells and cytokines within the first 5 days after surgery The changes of peripheral subtype of T-helper, myeloid-derived suppressor cells(MDSCs) and cytokines
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Zhong Shan Hospital Fudan University
🇨🇳Shanghai, Shanghai, China
Zhong Shan Hospital Fudan University🇨🇳Shanghai, Shanghai, China