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Clinical Trials/NCT01325844
NCT01325844
Completed
N/A

The Effects of Epidural Anesthesia on the Bioavailability of Nitric Oxide and Renal Function in Patients Undergoing Laparoscopic Surgery

Yonsei University1 site in 1 country45 target enrollmentNovember 2010
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ConditionsProstate Cancer

Overview

Phase
N/A
Intervention
Not specified
Conditions
Prostate Cancer
Sponsor
Yonsei University
Enrollment
45
Locations
1
Primary Endpoint
blood pressure with heart rate variability
Status
Completed
Last Updated
14 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

This study was designed to investigate the effects of epidural anesthesia combined with general anesthesia during laparoscopic surgery. The investigators hypothesized that epidural anesthesia will effectively block the activation of the sympathetic nervous system during surgery, thus activating nitric oxide and reducing splanchnic ischemia and decrease in postoperative renal function.

Registry
clinicaltrials.gov
Start Date
November 2010
End Date
October 2011
Last Updated
14 years ago
Study Type
Interventional
Study Design
Parallel
Sex
Male

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • •ASA class 1 or 2 adult patients scheduled for endoscopic prostatectomy

Exclusion Criteria

  • •Patient refusal
  • •Patients on diuretics
  • •Patients with renal failure (eGFR \< 60 ml/min/1.73 m2)

Outcomes

Primary Outcomes

blood pressure with heart rate variability

Time Frame: 10 minutes after anesthesia induction

Study Sites (1)

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