The Effects of Epidural Anesthesia on the Bioavailability of Nitric Oxide and Renal Function in Patients Undergoing Laparoscopic Surgery
Not Applicable
Completed
- Conditions
- Prostate Cancer
- Registration Number
- NCT01325844
- Lead Sponsor
- Yonsei University
- Brief Summary
This study was designed to investigate the effects of epidural anesthesia combined with general anesthesia during laparoscopic surgery. The investigators hypothesized that epidural anesthesia will effectively block the activation of the sympathetic nervous system during surgery, thus activating nitric oxide and reducing splanchnic ischemia and decrease in postoperative renal function.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 45
Inclusion Criteria
- ASA class 1 or 2 adult patients scheduled for endoscopic prostatectomy
Exclusion Criteria
- Patient refusal
- Patients on diuretics
- Patients with renal failure (eGFR < 60 ml/min/1.73 m2)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method blood pressure with heart rate variability 10 minutes after anesthesia induction
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms link epidural anesthesia to nitric oxide bioavailability in prostate cancer patients undergoing laparoscopic surgery?
How does the combination of epidural and general anesthesia compare to standard general anesthesia in preserving postoperative renal function for prostate cancer patients?
Are there specific biomarkers that predict enhanced nitric oxide activation and reduced splanchnic ischemia with epidural anesthesia in laparoscopic prostate cancer surgery?
What adverse events are associated with epidural anesthesia in laparoscopic prostate cancer surgery and how are they managed?
What other anesthetic agents or combination therapies have been studied for their effects on nitric oxide pathways and renal outcomes in prostate cancer surgery?
Trial Locations
- Locations (1)
Severance Hospital
🇰🇷Seoul, Korea, Republic of
Severance Hospital🇰🇷Seoul, Korea, Republic of