Diagnostic criteria for Multiple Sclerosis: Impact of high field Magnetic Resonance Imaging
Completed
- Conditions
- MSmultiple sclerosis1000381610012303
- Registration Number
- NL-OMON40083
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
CIS suggestive of MS as defined by the International Panel
Age 18-59 years
Exclusion Criteria
Vascular, malignant or other immunological diseases at present or in the past medical history;MRI related exclusion criteria:
- Claustrophobia
- Foreign non MR compatible metal objects in the body
- Foreign metal objects in or close to the head
- Allergic reaction to contrast administration in the past (only for patients)
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Primary endpoint of the study is MS lesion count: MR images from standard field<br /><br>1.5T and high field 3T will be compared using total amount of lesions and<br /><br>region specific amount of lesions. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary endpoints of the study: Data on cortical lesions: a double-inversion<br /><br>recovery (DIR) sequence is also included in the scanning protocol. This gray<br /><br>matter specific sequence leads to higher detection of cortical lesions. There<br /><br>is limited data on the quality of DIR at the various field strengths and<br /><br>vendors.</p><br>