NL-OMON24635尚未招募不适用
Pentoxifylline dose optimization in preterm neonatal sepsis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •Neonates with gestational age <30 weeks
- •- suspected of late onset sepsis with blood drawn for blood culture and
- •inflammatory biomarkers
- •- IL-6 >500 pg/mL or CRP >50 mg/L at onset
排除标准
- •- PTX therapy cannot be started within 24 hours of start of antibiotic treatment.
- •- Patients with major congenital defects (e.g. congenital heart disease,
- •pulmonary, or gastrointestinal anomalies) will also be excluded.
- •- If subjects have IL-6 values exceeding 25000 pg/mL at time of onset they will also be excluded. High IL-6 values represent severe episodes of sepsis and high IL-6 values are associated with high mortality rates.
- •- Patients who already participated in this trial during an earlier episode of late onset sepsis.
- •- pH below 7 in two consecutive blood samples, with at least 1 hour between the blood samples, at onset of sepsis
研究者
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