Pentoxifylline dose optimization in neonatal sepsis. - Pentoxifylline in neonatal sepsis

Erasmus University Medical Center0 个研究点目标入组 40 人开始时间: 2021年3月29日最近更新: 2021年11月8日

试验速览

暂无简介。

•- Neonates with gestational age <30 weeks
•- Suspected of sepsis with blood drawn for blood culture and inflammatory biomarkers
•- IL-6 > 500 pg/ml or if CRP > 50 mg/L
•Are the trial subjects under 18? yes
•Number of subjects for this age range: 40
•F.1.2 Adults (18-64 years) no
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•- PTX therapy cannot be started within 24 hours of start of antibiotic treatment.
•- Patients with major congenital defects (e.g. congenital heart disease, pulmonary, or gastrointestinal anomalies) will also be excluded.
•- If subjects have IL-6 values exceeding 25000 pg/mL at time of onset they will also be excluded. High IL-6 values represent severe episodes of sepsis and high IL-6 values are associated with high mortality rates.
•- Patients who already participated in this trial during an earlier episode of late onset sepsis.
•- Patients with pH below 7 in two consecutive blood samples, with at least 1 hour between the blood samples, at start of sepsis episode.

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