Study of the effects of aerobic physical training associated with drug treatment on blood pressure and heart rate in men with high blood pressure

Not Applicable

• Conditions: hypertension; Cardiovascular diseases; Hypertensive heart disease

• Registration Number: RBR-8k2dsc
• Lead Sponsor: Faculdade de Medicina de Ribeirão Preto

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-09-18
• Study Completion: 2020-12-01
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruitment completed
• Sex: Male
• Target Recruitment: Not specified

Inclusion Criteria

Hypertensive men; sedentary; age 35 to 65 years; use of Enalapril Maleate or Losartan monotherapy; at least 6 months of pharmacological treatment; volunteers who, on medical recommendation, do not use antihypertensive drugs and who have the indication to perform aerobic physical training as the first therapeutic conduct in the treatment of hypertension

Exclusion Criteria

Cognitive impairment; musculoskeletal disorders; endocrine diseases; metabolic and cardiovascular diseases (except systemic arterial hypertension); smokers; use of combined drugs for hypertension or any other drug that interferes with cardiac functionality and cardiovascular autonomic control

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Hypertensive men who use the antihypertensive agents Enalapril Maleate or Losartan, as well as those who do not use medication to control blood pressure may present a decrease in sympathetic influence and increase in parasympathetic activity when evaluated by means of frequency spectral analysis and pre and post conditions the aerobic physical training program.;Hypertensive men may present metabolic alterations, evaluated through blood samples such as: increased glycemia and fasting insulin; increase in total cholesterol and fractions; increased triglycerides; increased C-reactive protein; increased levels of tumor necrosis factor alpha, interleukin-6, catecholamines and angiotensins I and II, these variables being influenced by the aerobic physical training program.

Secondary Outcome Measures

Name	Time	Method
The aerobic physical training program may be able to promote in all hypertensive men, from the three groups, the improvement of cardiorespiratory and metabolic function, such as the anaerobic threshold and the volume of oxygen consumed at the peak of exercise (VO2peak), evaluated by means of of the ergospirometric test.;The aerobic physical training program may still be able to promote changes in body composition, lowering body weight and consequently decreasing body fat and, in some cases, may further promote lean body mass.