Effect of Age on PRF Quality; Assessed by Evaluating Healing Outcomes of ARP
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 44
- 试验地点
- 1
- 主要终点
- Soft tissue dimension changes
研究概览
简要总结
This study will examine whether using PRF and your age are going to affect the healing and regeneration benefits gained from PRF.
详细描述
Platelet-rich fibrin (PRF) is commonly used to enhance gum tissue healing and reducing pain after tooth extraction and before placing a dental implant. 44 patients requiring a tooth extraction will be recruited and randomized to receive a collagen plug with or without platelet-rich fibrin.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age range: 20 to 80 years.
- •Patients must require tooth extraction (molars) as a result of caries, periodontal disease, tooth fracture or deemed unrestorable.
- •Non-infected sockets with intact buccal bone (≥1.5 mm in thickness measured through calipers)
- •Patients interested in implant placement following tooth extraction.
排除标准
- •Allergies or hypersensitivities to study related medications.
- •Hematologic disorders/blood dyscrasias.
- •Active infectious diseases of any kind.
- •Liver or kidney dysfunction/failure.
- •Uncontrolled diabetes (HbA1c > 8).
- •Active cancer treatment - such as active chemotherapy or radiation therapy.
- •Taking medications that will affect their bone healing (for example, bisphosphonates, Long-term NSAIDs use, Steroid).
- •Metabolic bone diseases that affect bone healing such as osteoporosis.
- •Pregnant or lactating women (self-reported).
- •Smoke 10 or more cigarettes per day (self-reported).
- •Poor oral hygiene.
- •Systemic diseases that compromise the immune system
- •Anti-coagulant therapy
研究组 & 干预措施
Platelet-rich fibrin group.
Following extraction, a Platelet-rich fibrin plug will be placed in the extraction socket and covered with a collagen plug.
干预措施: Socket preservation (Procedure)
Collagen plug only
Collagen plug only
干预措施: Socket preservation (Procedure)
结局指标
主要结局
Soft tissue dimension changes
时间窗: 4 months
Digitally measured soft tissue changes in mm\^2 using intraoral scans
Alveolar ridge dimension changes
时间窗: 4 months
Digitally measured alveolar ridge dimension changes in mm\^2 using cone-beam computed tomography
次要结局
- Histological bone density.(4 months)
- Presence of bone turnover proteins.(4 months)
- Amount of growth factors(At baseline surgery)
- Wound healing index(1 week, 2 weeks, 4 weeks, and 8 weeks)
研究者
Muhammad Saleh
Clinical Assistant Professor, Periodontics and Oral Medicine
University of Michigan