Intracellular levels of magnesium and phosphate in patients with renal hypomagnesemia and hypophosphatemia: a pilot observational study

Recruiting

• Conditions: Hypomagnesemia/hypophosphatemia; low blood magnesium/phosphate; low serum magnesium/phosphate; 10029149

• Registration Number: NL-OMON49432
• Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

- Symptomatic renal hypomagnesemia or hypophosphatemia
- Patient is about to start with regular supplementation therapy (oral or
intravenous supplementation) or therapy is planned to be intensified based on
insufficient response on the previous treatment (increasing oral
supplementation or addition of intravenous supplementation on top of oral
supplementation)
- Age >= 16 years
- Informed consent

Exclusion Criteria

- patients who are pregnant at time of inclusion

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Intracellular levels of magnesium or phosphate in erythrocytes, peripheral<br /><br>blood mononuclear cells and skeletal muscle before and after supplementation of<br /><br>magnesium and phosphate</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Serum magnesium or phosphate<br /><br>- Personalized symptom score sheet<br /><br>- ATP levels in skeletal muscle cells (measured by 31P NMR)</p><br>