Visual Snow: Studying the visual snow phenotype and shared mechanisms with migraine pathophysiology

Recruiting

• Conditions: visual snow; visual tv static; 10047518; 10019231

• Registration Number: NL-OMON45361
• Lead Sponsor: eurologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 250

Inclusion Criteria

General
* Age *18 years (and <50 for those participating in MRS)
* Ability and willingness to provide written informed consent;Visual snow syndrome
* Visual disturbances suggestive of visual snow (for detailed clinical description)
* Clinical diagnosis of the visual snow syndrome (for case-control measurements);HPPD
* Continuous visual disturbances that started after drug intoxication (for detailed clinical description)
* Clinical diagnosis of visual snow starting after drug use (for case-control measurements) ;Migraine patients with frequent auras
* Meeting diagnostic criteria for migraine with aura (ICHD-III beta)
* At least one visual migraine aura per month (average of the past 6 months)
* For clinical description patients with atypical visual auras (visual symptoms mimicking visual snow description, visual auras longer than 1 hour) can also be included. For case-control measurement we aim for a homogenous study group and atypical auras are therefore excluded.;Tinnitus
* Daily complaints of tinnitus;Healthy controls
* See exclusion criteria

Exclusion Criteria

General exclusion criteria for those willing to participate in case-control measurements
* Subjects who do not want to be informed about unexpected findings that are considered serious and have prognostic or therapeutic consequences
* Schizophrenia, bipolar disorder, other psychotic disorders in medical history or current clinical suspicion of psychosis (delusions)
* Malignancy in medical history
* Central nervous system disease in medical history (other than migraine)
* For those participating in MRS: Pacemaker or ICD, Metal implants which cannot be removed, Pregnancy, Claustrophobia;Visual snow
* Underlying neurological disorder or ophthalmological disorder explaining symptoms (for case-control measurements only (3.2), not an exclusion criterion for clinical description (3.1)) ;HPPD
* Underlying neurological disorder or ophthalmological disorder explaining symptoms (for case-control measurements only (3.2), not an exclusion criterion for clinical description (3.1))
* Clinical suspicion that visual symptoms are part of psychosis, delirium, neurodegenerative disease or hypnopompic hallucinations ;Migraine patients with frequent auras
* Meeting criteria for any other (comorbid) headache disorder except for tension type headache
* Clinical suspicion that patient has Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL; often presents with frequent auras) or any other hereditary cerebral amyloid angiopathy
* (History of) ophthalmological disease other than refraction error
* (History of) chronic tinnitus;Tinnitus patients
* Any symptoms of migraine, cluster headache, chronic tension type headache or medication overuse headache
* (History of) ophthalmological disease other than refraction error;Healthy controls
* Any symptoms of migraine, cluster headache, chronic tension type headache or medication overuse headache
* (History of) ophthalmological disease other than refraction error
* (History of) chronic tinnitus

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. Detailed clinical information on different visual symptoms, non-visual<br /><br>symptoms, triggers, (psychiatric and neurological) comorbidities and<br /><br>psychological well-being; including data from prospective follow-up.<br /><br>2. Quantitative data on visual sensitivity and EEG and VEP profiles with<br /><br>specific parameters (amplitude of the posterior dominant rhythm, photic drive<br /><br>response); including diagnostic test characteristics.<br /><br>3. Concentrations of multiple metabolites both in vivo (MRS) and ex vivo<br /><br>(blood, urine).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable</p><br>