sefulness of oxygen reserve index (ORI) to avoid excessive hyperoxia undergoing orthopedic or general trauma surgery during general anesthesia: A prospective, randomized, open study

Not Applicable

Recruiting

Conditions: Injury, poisoning and certain other consequences of external causes

Registration Number: KCT0008379

Lead Sponsor: Ajou University Hospital

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 54

Inclusion Criteria

Trauma patients undergoing orthopedic or trauma surgery under general anesthesia
Patients with ASA class 3 or higher
Patients who have already had invasive arterial line or are scheduled to be placed and monitored during surgery
Age: 20 to 79 years old
Multiple trauma with/without heart or lung contusion
Patients undergoing induction of general anesthesia in the operating room or already intubated in a trauma bay or ICU
Patients with sufficient lung function to tolerate an initial FiO2 of up to 0.5 immediately after intubation
Acute Respiratory Distress Syndrome ARDS, depending on the severity of ARDS, patients who can maintain SpO2 above 95% with an initial FiO2 of 0.5
If the consent of the principal or a guardian in a legal representative relationship (when the consent of the individual is impossible due to intubation, etc.) can be obtained in advance

Exclusion Criteria

Patients unable to maintain an SpO2 of 95 or higher from an initial FiO2 of 0.5 immediately after intubation
pregnancy

Study & Design

Study Type: Interventional Study

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of hyperoxia ;The percentage of hours with moderate hyperoxia

Secondary Outcome Measures

Name	Time	Method
Minimum and maximum intraoperative FiO2 ;Minimum and maximum intraoperative PaO2 ;Number of hours with PaO2 equal or above to 100, 150, and 200 mmHg ;Number of intraoperative hypoxemia episode(defined by PaO2<60 mmHg);Number of atelectasis episodes, pneumonia, pulmonary edema, respiratory failure, surgical site infection, sepsis, mortality (within 7 days & within 28 days)