NCT01128790CompletedNot Applicable
Effect of Remote Ischemic Preconditioning on Exercise Capacity in Patients With Heart Failure: A Double Blind Randomized Control Trial
University Health Network, Toronto1 site in 1 country22 target enrollmentStarted: October 1, 2009Last updated:
Conditions
Interventions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 22
- Locations
- 1
- Primary Endpoint
- Exercise performance - VO2, exercise time, exercise workload, anaerobic threshold
Study Overview
Brief Summary
The purpose of this study is to determine the effect of remote ischemic preconditioning on exercise capacity in patients with heart failure.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Treatment
- Masking
- Triple (Participant, Care Provider, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •LV ejection fraction <40%
- •NYHA functional class II-IV
- •Non ischemic cardiomyopathy
Exclusion Criteria
- •recent cardiovascular hospitalization (within last 4 weeks)
- •ischemic cardiomyopathy
- •diabetes mellitus
- •peripheral neuropathy
- •ventricular assist device
- •contraindications to exercise stress testing
Arms & Interventions
remote ischemic preconditioning
Experimental
4 cycles of 5 mins upper limb ischemia induced by blood pressure cuff inflation 20mmHg above systolic blood pressure
Intervention: Remote ischemic preconditioning (Other)
Sham control
Sham Comparator
4 x 5 mins of upper limb blood pressure cuff inflation to 10mmHg (non-occlusive)
Intervention: Sham Control (Other)
Outcomes
Primary Outcomes
Exercise performance - VO2, exercise time, exercise workload, anaerobic threshold
Time Frame: 1 week
Secondary Outcomes
No secondary outcomes reported
Investigators
Study Sites (1)
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