In vivo analysis of the 11-beta-hydroxysteroid dehydrogenase activity during critical illness using isotopically labeled cortisol and cortisone
Completed
- Conditions
- Critical illnessNot Applicable
- Registration Number
- ISRCTN08083905
- Lead Sponsor
- Catholic University Leuven (Katholieke Universiteit Leuven) (Belgium)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 22
Inclusion Criteria
Current inclusion criteria as of 15/02/2012
For patients:
1. Admitted to the surgical intensive care unit (SICU) of the Leuven University Hospital
2. No age limits, either sex
For healthy control persons:
1. Age- and gender-matched to the included patients
Previous inclusion criteria
For patients:
1. Admitted to the surgical intensive care unit (SICU) of the Leuven University Hospital
2. Estimated duration of illness prior to admission less than 48 hours
3. No age limits, either sex
For healthy control persons:
1. Age- and gender-matched to the included patients
Exclusion Criteria
Steroids received during the last 3 months
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Current primary outcome(s) as of 15/02/2012<br>An estimation of the amount of ACTH-driven cortisol production , the amount of cortisol regenerated from cortisone via 11-beta-HSD1and 2 and the activity of the different metabolizing enzymes based on urinary metabolites.<br><br>Previous primary outcome(s)<br>An estimation of the amount of ACTH-driven cortisol production and the amount of cortisol regenerated from cortisone via 11-beta-HSD1, measured at day 2 and 7 after admission.
- Secondary Outcome Measures
Name Time Method o secondary outcome measures