Changes in patients undergoing craniotomy and tumors excision time
Not Applicable
- Conditions
- Health Condition 1: G061- Intraspinal abscess and granuloma
- Registration Number
- CTRI/2023/09/057774
- Lead Sponsor
- Department of Neurosurgery
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patient of either sex, Age group of 18-60 years
ASA Grade I and II
Elective Supratentorial Craniotomy
Exclusion Criteria
Patient refusal
Hyponatremia or Hypernatremia (Serum Na <130 or >150 mEq/L)
Pregnancy
Cardiac dysfunction with dysrhythmia
Renal dysfunction
History of recent craniotomy/Head injury ( <1year)
Active psychiatric or neurological disorders
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method •To compare the effect of equimolar 3% Hypertonic Saline, 8.4 % Sodium Bicarbonate & 20% mannitol on intracranial pressure (ICP).Timepoint: 48 hrs to 72 hrs
- Secondary Outcome Measures
Name Time Method To compare the following parameters between the groups: Cerebral perfusion pressure (CPP), Brain relaxation, Metabolic changes (ABG, Serum Osmolarity) & electrolytes, Hemodynamic parameters Heart Rate (HR), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Mean Arterial Pressure (MAP), Central Venous Pressure (CVP). The neurological outcome at the time of discharge of patient from the hospital (Extended Glasgow Outcome Scale (GOS-E), Complications if any like Hypotension, hyponatremia, hypernatremia, hyperkalemia, hypokalaemiaTimepoint: at the time of surgery