Anesthetic occupational exposure during medical residency - impact on oxidative stress and toxicogenomic, biochemical and neuroendocrine assessments: longitudinal study
Not Applicable
- Conditions
- 1) Genotoxicity2) Occupational Exposure3) Diseases of the endocrine system4) Immune system disorders
- Registration Number
- RBR-4vvkhz
- Lead Sponsor
- Departamento de Anestesiologia
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruitment completed
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
Start of medical residency in 2015 in anesthesiology areas; general surgery; orthopedics; neurosurgery; healthy volunteers; both genders; age between 18 and 35 years
Exclusion Criteria
Have done medical residence in the areas of interest of the study; Carrier malignancy; be more than 35 years of age
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method As expected, the potential increase in DNA damage detected by the comet assay, cytotoxicity assessed by flow cytometry, oxidative stress from protein and lipid oxidation markers by immunoassay (ELISA), and biochemical markers for dry and hormonal chemistry by chemiluminescence during the time of occupational exposure of study participants. The tests using<br>all the mentioned markers are in progress and the sample size was calculated based on the MDA (lipid oxidation marker) evaluation, determining 23 individuals, with 95% test power.
- Secondary Outcome Measures
Name Time Method Secondary outcomes are not expected