Clinical study to assess the dose of anaesthetic medications required for general anaesthesia during neurosurgeries, in patients who are on two or more medications for epilepsy.

Not Applicable

• Conditions: Health Condition 1: G402- Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizuresHealth Condition 2: G402- Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures

• Registration Number: CTRI/2019/04/018411
• Lead Sponsor: Sree chitra tirunal institute for medical sciences and technology

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

1. Consenting adult patients of either sex, with age 18 years to 60 years yrs with medically refractory seizure disorder coming for elective surgery in NSOT in our hospital

2. ASA grade I or II undergoing surgery

Exclusion Criteria

Exclusion criteria

1. Refusal by the patient or patient relatives

2. Patients of age <18 or >60 years

3. pregnant and nursing mothers

4. Coronary artery disease

5. Renal dysfunction

6. ASA grade 3 and above

7. Patients on anti tubercular treatment

8. patients with hepatic dysfunction

9. Patients with hypoalbuminemia

10. Obese patients with BMI > 30

11. Allergy to anaesthetic drugs

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
comparison of effect site concentration of Propofol in epilepsy patients on different types of Anti epileptic medications ( enzyme inducers, enzyme inhibitors and Benzodiazepines)Timepoint: Propofol dose required <br/ ><br>1. during maintainance of general anaesthesia <br/ ><br>

Secondary Outcome Measures

Name	Time	Method
comparison of effect site concentration of Propofol in epilepsy patients on different types of Anti epileptic medications ( enzyme inducers, enzyme inhibitors and Benzodiazepines)Timepoint: 1. at the time of induction <br/ ><br>2. recovery parameters like time required for emergence, extubation <br/ ><br>3. awareness during anaesthesia