Pharmacokinetic-Pharmacodynamic Modelling of Sevoflurane

Not Applicable

• Conditions: Pharmacokinetics and pharmacodynamics of sevoflurane; Anaesthesiology - Anaesthetics

• Registration Number: ACTRN12612001296820
• Lead Sponsor: Auckland City Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-12-14
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Adults undergoing surgery requiring general anaesthesia and use of a volatile anaesthetic
- Surgery expected to last at least one hour

Exclusion Criteria

- Unable to consent
- Surgery often associated with blood loss mandating blood transfusion, pregnant
- Unable to monitor bispectral index

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Arterial concentration of sevoflurane[Before the start of general anaesthesia, at 2 minute, 4 minutes, 8 minute, 16 minute, 32 minute then every 15~30 minute. The interval after 32nd minutes of anaesthesia will be determined by the clinical situations and recommendation of attending doctors. If they prefer to monitor arterial pressure reading at the particular moment, we will hold off taking arterial samples as arterial pressure can not be read briefly while arterial sample is being taken. As by 32nd minute the sevoflurane concentration in endtidal and arterial sample should be stablised, taking samples at either 15 minute interval or 30 min interval should not vary too much.<br>All the outcomes will be measured as long patient is anaesthetised.];End-tidal concentrations of sevoflurane[This will be measured continuously using anaesthetic machine];Bispectral monitoring data[This will be measured continuously using BIS monitoring]

Secondary Outcome Measures

Name	Time	Method
Blood pressure[It will be measured continuously using arterial line until the end of anaesthesia. This is a routine anaesthetic practice.]