A Study of the Effects of Fish Protein Intake on Glucose Regulation in Overweight and Obese Adults.

Not Applicable

Completed

• Conditions: Obesity; Overweight

• Registration Number: NCT01641055
• Lead Sponsor: University of Bergen

Brief Summary

The purpose of this study is to compare the possible health benefits of intake of proteins from salmon, herring, cod and milk on glucose tolerance in overweight and obese adults. Overweight and obese subjects often have reduced glucose tolerance, and previous findings from a study on cod proteins suggested that glucose tolerance was improved.

Detailed Description

Participants receive 2.5g protein per day for 8 weeks as tablets.

Study Timeline

• Study Start: 2012-07
• Study First Submitted: 2012-07-12
• Study First Submitted QC: 2012-07-12
• Study First Posted: 2012-07-16
• Primary Completion: 2012-11
• Study Completion: 2012-11
• Status Verified: 2022-03
• Last Update Submitted: 2022-03-29
• Last Update Posted: 2022-04-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 93

Inclusion Criteria

• BMI above 27 kg/m2
• healthy

Exclusion Criteria

• fasting blood glucose above 7 mM
• medication that affects blood glucose, lipids and inflammatory status
• pregnancy or breastfeeding
• allergies to fish or milk
• intentional weight loss and large fluctuation in body weight
• a high consumption of fish
• an extreme diet
• use of fish oil, n-3 or multivitamin supplements

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Primary Outcome Measures

Name	Time	Method
Glucose regulation	8 weeks	Glucose will be measured in fasting and postprandial samples

Secondary Outcome Measures

Name	Time	Method
Changes in serum insulin, insulin C-peptide, non-esterified fatty acids, lipids, adiponectin, leptin and fatty acid composition	8 weeks
Changes in serum concentrations of vitamins	8 weeks
Comparisons of metabolites and co-factors involved in one-carbon metabolism in serum and urine	8 weeks	Concentrations of relevant metabolites and co-factors were measured in serum and urine
Changes in serum and urine concentrations of amino acids and their metabolites	8 weeks

Trial Locations

Locations (1)

Institute of Medicine, University of Bergen; 🇳🇴 Bergen, Norway