NCT01641055已完成不适用
A 8 wk Study to Compare the Effects of Proteins Various Fish Species (Salmon, Herring, Cod) and Milk on Glucose Regulation in Overweight and Obese Adults.
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 93
- 试验地点
- 1
- 主要终点
- Glucose regulation
研究概览
简要总结
The purpose of this study is to compare the possible health benefits of intake of proteins from salmon, herring, cod and milk on glucose tolerance in overweight and obese adults. Overweight and obese subjects often have reduced glucose tolerance, and previous findings from a study on cod proteins suggested that glucose tolerance was improved.
详细描述
Participants receive 2.5g protein per day for 8 weeks as tablets.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 69 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI above 27 kg/m2
排除标准
- •fasting blood glucose above 7 mM
- •medication that affects blood glucose, lipids and inflammatory status
- •pregnancy or breastfeeding
- •allergies to fish or milk
- •intentional weight loss and large fluctuation in body weight
- •a high consumption of fish
- •an extreme diet
- •use of fish oil, n-3 or multivitamin supplements
研究组 & 干预措施
Herring protein hydrolysate
Experimental
干预措施: Herring protein hydrolysate (Dietary Supplement)
Cod protein
Sham Comparator
干预措施: Cod protein (Dietary Supplement)
Salmon protein hydrolysate
Experimental
干预措施: Salmon protein hydrolysate (Dietary Supplement)
Milk protein
Placebo Comparator
干预措施: Milk protein (Dietary Supplement)
结局指标
主要结局
Glucose regulation
时间窗: 8 weeks
Glucose will be measured in fasting and postprandial samples
次要结局
- Changes in serum insulin, insulin C-peptide, non-esterified fatty acids, lipids, adiponectin, leptin and fatty acid composition(8 weeks)
- Changes in serum concentrations of vitamins(8 weeks)
- Comparisons of metabolites and co-factors involved in one-carbon metabolism in serum and urine(8 weeks)
- Changes in serum and urine concentrations of amino acids and their metabolites(8 weeks)
研究者
Oddrun Anita Gudbrandsen
PhD
University of Bergen
研究点 (1)
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