Remote Ischemia Pre-Conditioning in Patients Undergoing Partial Nephrectomy
Not Applicable
Terminated
- Conditions
- Renal Cell Carcinoma
- Registration Number
- NCT01771003
- Lead Sponsor
- University Health Network, Toronto
- Brief Summary
Partial Nephrectomy has become the standard treatment in patients with tumours \<7cm (T1). Even though this is a nephron sparing surgery, there is still potential for acute kidney injury, due to ischemia during the surgery. Remote Ischemia Preconditioning may prevent acute kidney injury and in turn chronic kidney disease. Remote Ischemia pre-conditioning involves applying a blood pressure cuff and inflating and deflating several times immediately prior to surgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 21
Inclusion Criteria
- Patient must be a candidate for laparoscopic partial nephrectomy
- ECOG Performance status of 0-1
Exclusion Criteria
- No diagnosis of any current cutaneous, vascular or neural disease in the right upper arm.
- If the patient received isoflurane for any indication during the operation
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Change in Kidney Function before and after surgery up to 2 weeks prior to surgery and up to 24 hrs post surgery To measure and compare kidney function (Cr, eGFR) and AKI biomarkers in patients undergoing partial nephrectomy with and without RIPC
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University Health Network
🇨🇦Toronto, Ontario, Canada
University Health Network🇨🇦Toronto, Ontario, Canada