Effect of Ketorolac and Remote Ischemic Preconditioning on Renal Ischemia-reperfusion Injury in Patients Undergoing Partial Nephrectomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- serum creatinine
研究概览
简要总结
Partial nephrectomy is a widely accepted alternative to radical nephrectomy in patients with clinically localized, unilateral renal cell carcinoma and a normal contralateral kidney. Interruption of renal blood flow via pedicle clamping is often necessary during partial nephrectomy, especially for complex tumors with deep parenchymal invasion. Ischemia-reperfusion injury is a complex process involving several mechanisms including renal vasoconstriction, extensive tubular damage and glomerular injury. The investigators will examine the postoperative renal function of patients who received intraoperative ketorolac and remote ischemic preconditioning during partial nephrectomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA l and ll
- •age 20-65
- •patients undergoing partial nephrectomy
排除标准
- •preoperative liver or renal dysfunction,
- •coagulopathy,
- •chronic alcoholism,
- •hypersensitivity of NSAID,
- •history of warfarin,
- •history of gastric ulcer
研究组 & 干预措施
Keromin Group
干预措施: Ketorolac tromethamine and remote ischemic preconditioning (Drug)
结局指标
主要结局
serum creatinine
时间窗: at baseline, 2 hr, 12hr, 24 hr, 48 hr, 72 hr after clamping release
次要结局
- serum NGAL(at base line, 2 hr, 12 hr after clamping release)
- Creatinine clearance(at baseline, 2 hr, 12hr, 24 hr, 48 hr, 72 hr after clamping release)
- urinary NAG(at base line, 2 hr, 12 hr after clamping release)