Optimization of the MRI protocol for imaging the sacral plexus and its branching nerves

Completed

Conditions: disfunctioning of the bladder
Neurogenic bladder
10010335

Registration Number: NL-OMON36634

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 10

Inclusion Criteria

- male or female volunteers
- age: 18 years and older
- the participant must willingly give written informed consent prior to the start of the study

Exclusion Criteria

- volunteers who underwent surgery in the past related to the lumbosacral spine or pelvis.
- volunteers with urologic problems in the past wherefor treated by the (pediatric) urologist
- volunteers with a general contraindication for MRI (including cardiovascular pacemakers, claustrofobia)
- volunteers with a BMI (body mass index) of < 18,5 or a BMI of >25 kg/m2. This is because fat can lead to distortion on the MRI images. A BMI between 18,5 and 25 kg/m2 is classified as 'normal weight' . BMI is calculated following the equation BMI = mass (kg)/ length^2 (cm).
-volunteers who don't want to be informed about incidentally discovered lesions
-employees of the Departments of Pediatric Urology and Radiology of the UMC Utrecht

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1) Image analysis of the visibility of the nerves of the sacral plexus and the<br /><br>pudendal nerve and pelvic nerve on the MRI images obtained with the different<br /><br>parameter settings following a score system.<br /><br><br /><br>2) Analysis of the anatomy of the sacral plexus. The branching of the roots<br /><br>will be assessed.<br /><br><br /><br>3) Image analysis of the Contrast to Noise Ratio (CNR) on the different MRI<br /><br>images obtained with the different parameter settings. The mean and SD's of the<br /><br>CNR's will be compared witch each other to assess the image quality.<br /><br><br /><br>4) Calculation of the apparent diffusion coefficient (ADC) and the fractional<br /><br>anisotropy (FA) to get insight in the nature of the diffusion. This in view of<br /><br>our follow-up study in children.</p><br>

Secondary Outcome Measures