esional epilepsy: the effects of surgical intervention on ictal onset zone and permissive neural networks
Completed
- Conditions
- 10009720Epilepsyseizures10039911
- Registration Number
- NL-OMON32984
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
Inclusion criteria for pharmacoresistant epilepsy patients are (1) adult (>18 years) patients who (2) undergo resective surgical treatment at the VUmc regarding the Dutch Collaborative Epilepsy Surgery Program and (3) have given written informed consent. ;For brain tumour patients with epilepsy, inclusion criteria are (1) adult (* 18 years) patients who (2) undergo resective surgical treatment of the tumour with epilepsy surgery techniques at the VUmc, (3) are suffering from epilepsy which was not pre-existent to the lesion and (4) have given written informed consent.
Exclusion Criteria
Exclusion criteria are (1) psychiatric disease or symptoms, (2) insufficient mastery of the Dutch language, (3) inability to communicate adequately.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameters are ECoG and MEG measures assessing functional<br /><br>connectivity and neuronal brain networks (clustering coefficient and path<br /><br>length), as well as the clinical measures of seizure frequency, epilepsy burden<br /><br>and cognition. </p><br>
- Secondary Outcome Measures
Name Time Method <p>This includes the MRI scans.</p><br>