Epilepsy surgery evaluation in patients with refractory epilepsy: prospective application of routine genetic testing - GENetics & Epilepsy Surgery 1 / GENES 1

eurologie0 个研究点目标入组 275 人开始时间: 待定最近更新: 2024年4月15日

适应症

试验速览

暂无简介。

•In order to be eligible to participate in this study, a subject must meet all of the following criteria:
•o The patient enters the presurgical evaluation program in one of the participating centers
•o No age limit
•o Patients and/or parents/legal representative are willing and able to give informed consent for participation in the study.
•o MRI-brain shows no abnormalities that are likely to be causative for the epilepsy (*MRI-negative*: As determined by the local neuroradiologist and MD team, independent of the used MR imaging protocol, field strength, or post-processing.);Cohort II
•o The patient entered the presurgical evaluation program in in the UMC Utrecht
•o No age limit
•o Patients and/or parents/legal representative are willing and able to give informed consent for participation in the study
•o The patient underwent surgery in the UMC Utrecht for drug-resistant FE and had MCD, GNT, or negative pathology

•A potential subject who meets any of the following criteria will be excluded from participation in this study:
•o No age exclusion criteria
•o Known genetic disorders at entry that are directly related to the patient*s epilepsy; genetic disorders not related to the epilepsy are not a reason for exclusion, however such conditions will be noted in the participant*s research file.

发起方

eurologie