Study to Examine the Effects of ATP Supplementation on Muscle Excitability and Reaction Time During and Following a Repeated Sprint Bout

Not Applicable

Completed

• Conditions: Muscle Fatigue Caused by Repetitive Muscle Exercise
• Interventions: Dietary Supplement: Placebo; Dietary Supplement: ATP

• Registration Number: NCT02093611
• Lead Sponsor: Metabolic Technologies Inc.

Brief Summary

We hypothesize that adenosine-5'-triphosphate (ATP) supplementation will be able to enhance motor unit recruitment while simultaneously blunting the decline in power and reaction time that is typically seen during repetitive sprints. This will give researchers a better understanding of the mechanism by which ATP supplementation can augment power, especially under high fatiguing conditions.

Detailed Description

Healthy participants of similar training status as previously tested will be enrolled into the study. The participants will be randomly assigned to either placebo supplementation or to 400 mg ATP per day for 14 days. The supplements will be taken in the morning and the last dose will be taken 30 min prior to testing on the last day. Testing will be performed at baseline and after the 14 days of supplementation. Ten successive sprints will be conducted on the Wingate apparatus as this has been previously demonstrated to decrease muscle excitability. After the sprints, muscle excitability, reaction time, and vertical jump power will be measured. In addition a blood sample will be obtained before and after supplementation and complete blood hematology and chemistry analyses will be performed. It is expected that ATP supplementation may help maintain muscle excitability and power after the successive sprint sessions.

Study Timeline

• Study Start: 2013-07
• Study First Submitted: 2014-03-18
• Study First Submitted QC: 2014-03-19
• Study First Posted: 2014-03-21
• Primary Completion: 2015-08
• Study Completion: 2015-08
• Status Verified: 2015-09
• Last Update Submitted: 2015-09-24
• Last Update Posted: 2015-09-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 42

Inclusion Criteria

• Agree to eating a diet approved by a registered dietician consisting of the following by caloric percentages: 15-20% protein, 44-55% carbohydrate, and 25-30% fat.
• Must not have taken performance enhancing supplements for at least 3 months prior to the study start,
• Must be a non-smoker.
• Must not be taking amino acid supplements.
• Must not be using anabolic or catabolic hormones.
• Must not be taking any medications known to influence variables to be measured in the study.

Exclusion Criteria

• Will not agree to eating a diet approved by a registered dietician consisting of the following by caloric percentages: 15-20% protein, 44-55% carbohydrate, and 25-30% fat.
• Has taken performance enhancing supplements for at least 3 months prior to the study start,
• Is currently a non-smoker.
• Is currently taking amino acid supplements.
• Is currently using anabolic or catabolic hormones.
• Is currently taking medications known to influence variables to be measured in the study.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo	Placebo	This arm will serve as the placebo supplementation.
ATP	ATP	This arm will serve as the treatment intervention, ATP

Primary Outcome Measures

Name	Time	Method
Muscle Excitability	Day 14	Muscle excitability will be measured using Delsys Wireless Electromyography (EMG) sensors.

Secondary Outcome Measures

Name	Time	Method
Power	Day 14	Muscle power will be measured using the Wingate and vertical jump power measures.

Trial Locations

Locations (1)

Jacob M Wilson, PhD; 🇺🇸 Tampa, Florida, United States