Pharmacological enhancement of motor function recovery in patients with ischaemic stroke: a trial of fluoxetine.

Phase 1

• Conditions: Stroke

• Registration Number: PACTR201412000967245
• Lead Sponsor: dike franklin

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-12-10
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

(1)18- 85yrs of age
(2)Ischaemic stroke, unilateral, supra-tentorialconfirmed by neuroimaging.
(3)Presentation within first 14 days of ictus
(4)NIHSS score (5)Hemiparesis or hemiplegia, FMMS (6)Informed consent.

Exclusion Criteria

(1) Glasgow coma score < 8,
(2) NIHSS score >16
(3)Cardiovascular/metabolic /respiratory instability-: hypertensive emergency or hypotension/ acidosis or alkalosis/ RR >24cycles per min.
(4)Previous central /peripheral nerve injury
(5)Concurrent medications interacting with SSRI¿s
(6)Haemorrhagic stroke on CT
(7)Substantial premorbid disability
(8)Depression (Montgomery-Åsberg Depression Rating Scale MADRS score >19), taking anti-depressant drugs, MAOI, neuroleptic drugs or benzodiazepines during the month before inclusion.
(9)Pregnancy.
(10)No consent.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in Fugl Meyr Motor score

Secondary Outcome Measures

Name	Time	Method
IHSS, mRS