Collection of Malignant Ascites, Pleural Fluid and Blood From Patients With Solid Tumors
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- To obtain blood samples, ascites and pleural effusion samples from patients with solid tumor malignancies, with the intent of performing translational studies related to cancer.
研究概览
简要总结
Background:
Researchers want to study fluids and blood of people with cancer. The fluids are from the abdomen and around the lungs. Studying these might help researchers learn about the biology of cancer. This may lead to better ways to treat cancer.
Objectives:
To study the biology of cancer.
Eligibility:
Adults 18 and older with malignant solid tumors.
Design:
Participants will be screened with medical history, blood tests, and confirmation of diagnosis.
Participants will have samples taken at regularly scheduled procedures. Fluids from the abdomen and/or lungs will be taken as part of the procedures. Blood will be taken separately.
Participants may be asked to give more samples at future procedures.
详细描述
Background:
-Malignant ascites or pleural effusions are often seen in patients with solid tumor
malignancies.
-Malignant ascites is proinflammatory with many cytokines present and acts to promote
tumor cell growth.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
To obtain blood samples, ascites and pleural effusion samples from patients with solid tumor malignancies, with the intent of performing translational studies related to cancer.
时间窗: Ongoing
Experimental - Translational study outcomes from the collection/analysis of blood samples; and ascites and pleural effusion samples from patients with solid tumor malignancies.
次要结局
- Develop the malignant fluid as a culture model to replicate intraperitoneal growth of ovarian cancers.(ongoing)
- Characterize malignant effusion composition through immunohistochemistry and flow cytometry.(ongoing)
- Compare immune cell phenotype in ascites and blood from the patient.(ongoing)
- Study in vivo characteristics of matched tumor cells and peripheral blood leukocytes from the same patient in xenograft models(ongoing)
- Establish a bank of clinically annotated samples for translational science.(ongoing)
- Compare selected matched sets of samples from the same patient to evaluate both for treatment response.(ongoing)