Repetitive Transcranial Magnetic Stimulation of the Posterior Parietal Cortex in Patients Suffering From Gilles de la Tourette Syndrome
Phase 2
Terminated
- Conditions
- TicsGilles de la Tourette Syndrome
- Interventions
- Device: Sham rTMSDevice: rTMS
- Registration Number
- NCT01043549
- Lead Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
- Brief Summary
Repetitive transcranial stimulation (rTMS) of the posterior parietal cortex will be applied daily over five days in adult Gilles de la Tourette patients. This approach aims at reducing premonitory sensations believed to induce tics. Patients will be randomized to an active or placebo (sham) group in a crossover design.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 5
Inclusion Criteria
- Gilles de la Tourette syndrome as defined by DSM IV-R
- Yale Global Tics Severity Scale (YGTSS) score between 30 et 60
- Premonitory sensations (" urge to move ")
- Affiliated to the French social security regime
- Ability to give informed consent
Exclusion Criteria
- rTMS : epilepsy, craniotomy scar, pacemaker or neural stimulator, metal implants or foreign bodies, claustrophobia, pregnancy
- Cognitive impairment (MMS ≤ 24/30)
- Axis I disorders according to DSM IV-R : psychosis or history of psychosis, bipolar illness, major depressive disorder, addictions (except to nicotine)
- Impulse control disorders
- Other chronic debilitating illnesses
- Unability to give informed consent
- Participation in another clinical trial
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Sham stimulation Sham rTMS - Stimulation rTMS Repetitive transcranial stimulation of the posterior parietal cortex
- Primary Outcome Measures
Name Time Method Yale global tic severity scale (YTGSS) 3 months
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Inserm U975
🇫🇷Paris, France